Grey’s Anatomy is known for its plot twists. The medical drama has been able to keep viewers engaged for 16 seasons by creating juicy storylines that fans could never see coming. Welp, in most recent news, the series might’ve just thrown in one of the most controversial twists in its history, in explaining what happened to Alex Karev, who has been absent from episodes since the end of 2019. Fans now know Karev left Jo for Izzie, but why? Grey’s Anatomy fans have a lot to wrap their heads around.
On the March 5 episode of Grey’s Anatomy, Karev’s storyline finally came to a close. But since he already made his final appearance on the show in 2019, there weren’t any big confrontation scenes with him in store for this episode. Rather, Alex Karev was heard as he narrated various handwritten letters he wrote to his friends and wife at Grey Sloan Hospital saying goodbye and explaining where he went. Flashbacks from past seasons accompanied his voice and helped viewers reminisce on everything that he left behind.
While some viewers are at ease now that it’s finally clear what happened to Karev, most others are shocked with Karev’s decision to leave his current wife Jo, for his ex flame Izzie. Karev explains in a letter to Meredith that he reconnected with Izzie when he was gathering letters to defend Meredith when her medical license was in danger of being suspended. Although he had always been curious about how she was, it wasn’t until then until he contacted her, and when he called he heard a child’s voice on the line.
Of course, in the plot twist of the century, the kids — yes kids, as in plural — he heard were his. The five-year-old twins, Alex and Eli, came from the embryos Izzie froze eons ago and Jo found out about in Season 12. Apparently Izzie finally used those embryos and was raising the children on her farm in Kansas, where she works as a surgical oncologist. All of this news come out in Karev’s farewell letter to Meredith, where he explains his children played a big part in his decision to leave Seattle and his current wife Jo. “I love Jo. Deeply. Still. I think I always will. And if it was just about two women I love, I’d choose my wife. You know I would," Karev wrote, shaking many viewers along the way.
As for Jo’s farewell letter? Alex recognizes leaving her for Izzie without warning isn’t his most noble act. “It’s officially the worst thing I’ve ever done,” he said, while explaining he didn’t want to miss any more of his kids’ lives and he couldn’t look her in the eyes to tell her this news in person. To slightly make up for it, he also said he left her with his shares to Grey-Sloan and sent her best wishes for finding someone else. Jo handles the news like the boss she is: She closes the letter and starts getting ready for her day at the hospital, like normal. Link, who was looking on as she read exclaimed: “You’re my hero," to which Jo responded: “Mine, too.”
The now Alex Karev-less Season 16 of Grey’s Anatomy continues on Thursdays at 9 p.m. ET on ABC.
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